Structural and Mechanistic Studies of Antimicrobial Actions
The theme of our laboratory is to study molecular mechanisms of how to interfere with bacteria, with the overarching aim to develop novel antimicrobial reagents to target bacterial infections. We work on essential bacterial processes and those nonessential for survival, with the latter having less selection pressure to develop resistance. To this end, we collaborate with microbiologists, chemical biologists, and biophysicists. Together, we employ a wide range of experimental approaches, including microbiology, genetics, chemical biology, molecular biology, combinatorial biology, biochemistry, biophysics, structural biology, and particularly protein crystallography.