Faculty of 1000 | Distinguishing between selection and population expansion in an experimental lineage of bacteriophage T7.

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Distinguishing between selection and population expansion in an experimental lineage of bacteriophage T7.
Hahn MW, Rausher MD, Cunningham CW
Genetics 2002 May 161(1):11-20 [abstract on PubMed] [related articles] [order article]

Selected by | Mohamed Noor
Evaluated 12 Jun 2002

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Mohamed Noor
Louisiana State University, United States
GENOMICS & GENETICS

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Hahn et al have refined existing methods of population genetic analyses to demonstrate how to distinguish among the signatures of positive selection, purifying selection, and demographic expansion. They demonstrate the efficacy of their methods using experimental lineages of bacteriophage T7, suggesting that the methods can work in natural populations. While the methodology is straightforward and remarkably easy-to-follow, it provides an extremely useful demonstration of how population genetic studies using sequences of multiple genes can be done in the future to maximize the amount of information obtained.

Evaluated 12 Jun 2002

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