Recent Representative Publications:

 

1.                Harris, R. S., G. Feng, K. J. Ross, R. Sidhy, C. Thulin, S. Longerich, S. K. Szigety, P. J. Hastings, M. E. Winkler, and S. M. Rosenberg. Mismatch repair is diminished during stationary-phase mutation. Mutation Res. 437: 51-60, 1999.

 

2.                B. Esberg, H.-C. E. Leung, H.-C. T. Tsui, G. R. Björk, and M. E. Winkler. Characterization of the miaB gene involved in the methylthiolation step of the biosynthesis of ms2i(o)6A37 in tRNA of S. typhimurium and E. coli. J. Bacteriol. 181: 7256-7265, 1999.

 

 

3.                Winkler, M.E. Bacterial Molecular Genetics for the New Millennium. Methods 20: 1-3, 2000.

 

4.                Zhao, J., and M.E. Winkler. Reduction of GC ® TA Transversion Mutation by Overexpression of MutS in Escherichia coli K-12.  J. Bacteriol. 182:5025-5028, 2000.

 

 

5.                Winkler, M. E. Genetic and Genomic Approaches for Delineating the Pathway of Pyridoxal 5’-Phosphate Coenzyme Biosynthesis in Escherichia coli, p.3-10. In A. Iriarte, H.M.Kagan, and M. Martinez-Carrion (ed.), Biochemistry and Molecular Biology of Vitamin B6 and PQQ-Dependent Proteins. Birkhauser Verlag, Berlin, 2000.

 

6.                Winkler, M. E. Genetic Approaches to the biosynthesis of small molecules. In S. Brenner and J. Miller (eds.), Encyclopedia of Genetics, Academic Press; 2001.

 

 

7.                Zhao, J., H.-C-. E. Leung, and M.E. Winkler. Genetic Requirements of the MiaA Mutator Phenotype Match Those of the Translation Stressed-Induced Pathway (TSM) in Escherichia coli K-12. J. Bacteriol. 183: 1796-1800, 2001.

 

8.                Hoskins, J.A. et al., The genome of the bacterium Streptococcus pneumoniae strain R6. J. Bacteriol. 183: 5709-5717, 2001.

 

 

9.                Pease, A.J., B.B. Roa, W. Luo, and M.E. Winkler. Positive Growth Rate-Dependent Regulation of the pdxA, ksgA, and pdxB Genes of Escherichia coli K-12. J. Bacteriol. 184: 1359-1369, 2002.

 

10.           Cabello-Villegas, J., M.E. Winkler, and E.P. Nikonowicz. Solution Conformation of Unmodified and A(37)N(6)-dimethyallyl-Modified Anticodon Stem-loops of Escherichai coli tRNA(Phe). J. Mol. Biol. 319:1015-1035, 2002.

 

 

11.           Robertson, G.T., W.L. Ng, J. Foley, R. Gilmour, and M.E. Winkler. Global Transcription Analysis of clpP Mutations of Type 2 Streptococcus pneunmoniae and Their Effects on Physiology and Virulence. J. Bacteriol. 184: 3508-3520, 2002.

 

12.           Robertson, G.T., J.Y. Zhao, B. Desai, B. Coleman, T.I. Nicas, R. Gilmour, L. Grinius, D. Morrison, and M.E. Winkler. Vancomycin Tolerance Induced by Erythromycin, But Not by Loss of vncRS, vex3, or pep27 Function in Streptococcus pneumoniae. J. Bacteriol. 184: 6987-7000, 2002.

 

 

13.           Roop, R.M., G.T. Robertson, G.P. Ferguson, L.E. Milford, M.E. Winkler, and G.C. Walker. Seeking a Niche: Putative Contributions of the hfq and bacA Gene Products to the Successful Adaptation of the Brucellae to their Intracellular Home. Vet. Microbiol. 2394: 1-15, 2002.

 

14.           Bayles, K.W., N.E. Welker, M.E. Winkler, and U.N. Streips, Report on the Wind River Conference on Prokaryotic Biology - 2002. J. Bacteriol, 185: 7-12, 2003.

 

 

15.           Ng, W.L., G.T. Robertson, K.M. Kazmierczak, R. Gilmour, and M.E. Winkler. Transcriptional Regulation and Signature Patterns Revealed by Microarray Analyses of Streptococcus pneumoniae R6 Challenged with Sub-Lethal Concentration of Translation Inhibitors. J. Bacteriol. 185: 359-370, 2003.

 

16.           Robertson, G.T., W.-L. Ng, R. Gilmour, and M.E. Winkler. Essentiality of clpX, but not clpP, clpL, clpC, or clpE, in Streptococcus pneumoniae R6. J. Bacteriol. 185:2961-2911, 2003.

 

 

17.           Li, B., H.-C. T. Tsui, J.E. LeClerc, M.Dey, M.E. Winkler, and T.A. Cebula. Molecular Analysis of mutS Expression and Mutation in Natural Isolates of Pathogenic Escherichia coli. Microbiology 149: 1323-1331, 2003.

 

18.           Roop, R.M., J.M. Gee, G.T. Robertson, J.M. Richardson, W.-L. Ng, and M.E. Winkler. Brucella Stationary Phase Gene Expression and Virulence. Annual Review of Microbiology 57:57-76, 2003.

 

 

19.           Ng, W.L. G.T. Robertson, K.M. Kazmierczak, J. Zhao, R. Gilmour, and M.E. Winkler. Constitutive Expression of PcsB Suppresses the Requirement for the Essential VicR (YycF) Response Regulator in Streptococcus pneumoniae R6. Molecular Microbiology 50:1647-63, 2003.

 

20.           Foster, J.E., Q. Sheng, J.R. McClain, M. Bures, T.I. Nicas, K. Henry, M.E. Winkler, and R. Gilmour. Kinetic and Mechanistic Analyses of New Classes of Inhibitors of Two-Component Signal Transduction Systems Using a Coupled Assay Containing HpkA-DrrA from Thermotoga maritima. Microbiology 150(4):885-96, 2004.

 

21.           Gooding KB, Higgs R, Hodge B, Stauffer E, Heinz B, McKnight K, Phipps K, Shapiro M, Winkler M, Ng WL, Julian RK. High throughput screening of library compounds against an oligonucleotide substructure of an RNA target. J Am Soc Mass Spectrom 15(6):884-92, 2004.

 

22.             Ng, W. L., K. M. Kazmierczak, and M. E. Winkler.Defective cell wall synthesis in Streptococcus pneumoniae R6 depleted for the essential PcsB putative murein hydrolase or the VicR (YycF) response regulator. Molecular Microbiology 53(4): 1161-1175, 2004.